Journal: Journal of Materials Science. Materials in Medicine

Article Title: Biofunctionalization strategies on tantalum-based materials for osseointegrative applications

doi: 10.1007/s10856-015-5445-z

Figure Lengend Snippet: Chemical structure of the cell adhesive RGD peptide

Article Snippet: Nonetheless, the only report studying the functionalization of Ta surfaces with a synthetic cell adhesive peptide corresponds to a recent work from McNichols et al., in which Ta substrates were coated with a cyclic RGD peptide to improve vascular endothelialization [ ].

Techniques: Adhesive

Journal: Journal of Materials Science. Materials in Medicine

Article Title: Biofunctionalization strategies on tantalum-based materials for osseointegrative applications

doi: 10.1007/s10856-015-5445-z

Figure Lengend Snippet: Water contact angle measurements and surface energy calculations. a Activation of Ta samples (Ta) by passivation (Ta HNO 3 ) or UV/ozone treatment (Ta ozone), and physical adsorption of RGD peptide (+RGD). b Activation of Ta samples (Ta) by passivation (Ta HNO 3 ) or UV/ozone treatment (Ta ozone), silanization (+APTES) and covalent attachment of RGD peptide (+RGD). Values are expressed as mean ± standard deviation. Letters ( a–e ) denote statistically significant differences (P < 0.05) between groups

Article Snippet: Nonetheless, the only report studying the functionalization of Ta surfaces with a synthetic cell adhesive peptide corresponds to a recent work from McNichols et al., in which Ta substrates were coated with a cyclic RGD peptide to improve vascular endothelialization [ ].

Techniques: Activation Assay, Adsorption, Standard Deviation

Journal: Journal of Materials Science. Materials in Medicine

Article Title: Biofunctionalization strategies on tantalum-based materials for osseointegrative applications

doi: 10.1007/s10856-015-5445-z

Figure Lengend Snippet: Curve-fitting deconvolution of high resolution XPS spectra (Ta 4p 3/2 and N 1s signals). a Control Ta samples (Ta). b Physical adsorption of RGD peptide on control surfaces (Ta + RGD). c Physical adsorption of RGD peptide on UV/ozone-treated surfaces (Ta ozone + RGD). d Covalent binding of RGD peptide via silanization on UV/ozone-treated surfaces (Ta ozone + APTES + RGD)

Article Snippet: Nonetheless, the only report studying the functionalization of Ta surfaces with a synthetic cell adhesive peptide corresponds to a recent work from McNichols et al., in which Ta substrates were coated with a cyclic RGD peptide to improve vascular endothelialization [ ].

Techniques: Control, Adsorption, Binding Assay

Journal: Journal of Materials Science. Materials in Medicine

Article Title: Biofunctionalization strategies on tantalum-based materials for osseointegrative applications

doi: 10.1007/s10856-015-5445-z

Figure Lengend Snippet: Adhesion of Saos-2 cells on Ta surfaces functionalized with the RGD peptide by physical adsorption. Cell adhesion was analyzed after 4 h of incubation. a Cell attachment (cells/cm 2 ); and b cell spreading (cell area in µm 2 ). Values are expressed as mean ± standard deviation. The symbol (*) denotes statistically significant differences between groups (cell numbers P < 0.1, cell area P < 0.05)

Article Snippet: Nonetheless, the only report studying the functionalization of Ta surfaces with a synthetic cell adhesive peptide corresponds to a recent work from McNichols et al., in which Ta substrates were coated with a cyclic RGD peptide to improve vascular endothelialization [ ].

Techniques: Adsorption, Incubation, Cell Attachment Assay, Standard Deviation

Journal: Journal of Materials Science. Materials in Medicine

Article Title: Biofunctionalization strategies on tantalum-based materials for osseointegrative applications

doi: 10.1007/s10856-015-5445-z

Figure Lengend Snippet: Adhesion of Saos-2 cells on Ta surfaces functionalized with the RGD peptide by silanization. The physisorption of RGD on Ta was also included as control. Cell adhesion was analyzed after 4 h of incubation. a Cell attachment (cells/cm 2 ); and b cell spreading (cell area in µm 2 ). Values are expressed as mean ± standard deviation. The symbol (*) denotes statistically significant differences between groups (cell numbers P < 0.1, cell area P < 0.05)

Article Snippet: Nonetheless, the only report studying the functionalization of Ta surfaces with a synthetic cell adhesive peptide corresponds to a recent work from McNichols et al., in which Ta substrates were coated with a cyclic RGD peptide to improve vascular endothelialization [ ].

Techniques: Control, Incubation, Cell Attachment Assay, Standard Deviation